Drug interactions
Magnesium hydroxide + Omadacycline
Severity: Moderate
Magnesium hydroxide and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium in antacids forms poorly absorbed complexes with omadacycline, lowering its absorption and possibly causing treatment failure.
What this interaction means in plain words
Magnesium hydroxide and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
Why it happens
Chelation of omadacycline by multivalent magnesium cations in the gut reduces absorption.
What to do
Separate dosing: omadacycline labeling advises taking it at least 4 hours before or 2 hours after products containing magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Magnesium hydroxide with Omadacycline?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium in antacids forms poorly absorbed complexes with omadacycline, lowering its absorption and possibly causing treatment failure.
How serious is the interaction between Magnesium hydroxide and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing: omadacycline labeling advises taking it at least 4 hours before or 2 hours after products containing magnesium.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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