Drug interactions
Magnesium oxide + Moxifloxacin
Severity: Moderate
Magnesium oxide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing antacids and supplements bind moxifloxacin in the gut and decrease its absorption, which may result in subtherapeutic antibiotic levels.
What this interaction means in plain words
Magnesium oxide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium oxide belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of moxifloxacin by magnesium cations in the gastrointestinal tract.
What to do
Take oral moxifloxacin at least 4 hours before or 8 hours after magnesium oxide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Magnesium oxide with Moxifloxacin?
MediHelp rates the interaction as moderate. Magnesium oxide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids and supplements bind moxifloxacin in the gut and decrease its absorption, which may result in subtherapeutic antibiotic levels.
How serious is the interaction between Magnesium oxide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take oral moxifloxacin at least 4 hours before or 8 hours after magnesium oxide.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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