Drug interactions
Magnesium sulphate + Nifedipine
Severity: Moderate
Magnesium sulphate and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral magnesium and nifedipine used together, for example in obstetric care, may cause additive hypotension. Rare reports describe exaggerated neuromuscular weakness.
What this interaction means in plain words
Magnesium sulphate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium sulphate belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive calcium channel antagonism and vasodilation, with magnesium contributing to neuromuscular depression.
What to do
Monitor blood pressure, deep tendon reflexes and respiratory rate, and check serum magnesium. Reduce doses if hypotension or weakness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Nifedipine
Frequently asked questions
Can I take Magnesium sulphate with Nifedipine?
MediHelp rates the interaction as moderate. Magnesium sulphate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium and nifedipine used together, for example in obstetric care, may cause additive hypotension. Rare reports describe exaggerated neuromuscular weakness.
How serious is the interaction between Magnesium sulphate and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, deep tendon reflexes and respiratory rate, and check serum magnesium. Reduce doses if hypotension or weakness occurs.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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