Drug interactions
Magnesium sulphate + Penicillamine
Severity: Moderate
Magnesium sulphate and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium-containing products may bind penicillamine and reduce its absorption, weakening its therapeutic effect. This applies to oral magnesium, not parenteral use.
What this interaction means in plain words
Magnesium sulphate and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium sulphate belongs to Cardiovascular; Penicillamine belongs to Musculoskeletal.
Why it happens
Chelation of penicillamine by magnesium in the gastrointestinal tract reduces its absorption.
What to do
Separate oral penicillamine and magnesium products by at least 2 hours and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Frequently asked questions
Can I take Magnesium sulphate with Penicillamine?
MediHelp rates the interaction as moderate. Magnesium sulphate and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium-containing products may bind penicillamine and reduce its absorption, weakening its therapeutic effect. This applies to oral magnesium, not parenteral use.
How serious is the interaction between Magnesium sulphate and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral penicillamine and magnesium products by at least 2 hours and monitor clinical response.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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