Drug interactions
Magnesium sulphate + Rocuronium
Severity: Moderate
Magnesium sulphate and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral magnesium sulfate enhances rocuronium neuromuscular blockade, shortening onset and prolonging duration. Recovery may be delayed, with a risk of residual paralysis.
What this interaction means in plain words
Magnesium sulphate and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium sulphate belongs to Cardiovascular; Rocuronium belongs to Musculoskeletal.
Why it happens
Magnesium reduces presynaptic acetylcholine release and postsynaptic sensitivity, adding to competitive blockade.
What to do
Reduce rocuronium dose and use quantitative train-of-four monitoring. Confirm full recovery before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Magnesium sulphate and Rocuronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Rocuronium
Frequently asked questions
Can I take Magnesium sulphate with Rocuronium?
MediHelp rates the interaction as moderate. Magnesium sulphate and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate enhances rocuronium neuromuscular blockade, shortening onset and prolonging duration. Recovery may be delayed, with a risk of residual paralysis.
How serious is the interaction between Magnesium sulphate and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce rocuronium dose and use quantitative train-of-four monitoring. Confirm full recovery before extubation.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
