Drug interactions
Magnesium sulphate + Streptomycin
Severity: Moderate
Magnesium sulphate and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium wasting, and both they and magnesium impair neuromuscular transmission. Combined use may reduce magnesium levels and increase the chance of muscle weakness or respiratory depression.
What this interaction means in plain words
Magnesium sulphate and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium sulphate belongs to Cardiovascular; Streptomycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside-induced tubular magnesium loss plus additive neuromuscular blockade.
What to do
Monitor serum magnesium and respiratory and neuromuscular status; replace magnesium as needed and avoid in myasthenia gravis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Streptomycin
Frequently asked questions
Can I take Magnesium sulphate with Streptomycin?
MediHelp rates the interaction as moderate. Magnesium sulphate and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, and both they and magnesium impair neuromuscular transmission. Combined use may reduce magnesium levels and increase the chance of muscle weakness or respiratory depression.
How serious is the interaction between Magnesium sulphate and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and respiratory and neuromuscular status; replace magnesium as needed and avoid in myasthenia gravis.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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