Drug interactions
Magnesium sulphate + Tobramycin
Severity: Moderate
Magnesium sulphate and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobramycin can cause renal magnesium wasting and hypomagnesemia, and both agents impair neuromuscular transmission. Concurrent use may reduce magnesium effect and enhance neuromuscular weakness.
What this interaction means in plain words
Magnesium sulphate and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium sulphate belongs to Cardiovascular; Tobramycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside tubular toxicity increases magnesium excretion, with additive neuromuscular blockade.
What to do
Monitor serum magnesium, renal function and neuromuscular or respiratory status; replace magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Magnesium sulphate and Tobramycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Magnesium sulphate with Tobramycin?
MediHelp rates the interaction as moderate. Magnesium sulphate and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tobramycin can cause renal magnesium wasting and hypomagnesemia, and both agents impair neuromuscular transmission. Concurrent use may reduce magnesium effect and enhance neuromuscular weakness.
How serious is the interaction between Magnesium sulphate and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, renal function and neuromuscular or respiratory status; replace magnesium as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
