Drug interactions
Maprotiline + Melatonin
Severity: Minor
Maprotiline and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative effects and may add to the drowsiness caused by maprotiline. The clinical effect is generally modest and is often used deliberately for sleep.
What this interaction means in plain words
Maprotiline and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive mild sedative effects; no significant pharmacokinetic interaction is established.
What to do
Counsel the patient about possible daytime drowsiness and reduce the melatonin dose or take it earlier in the evening if next-day sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Maprotiline with Melatonin?
MediHelp rates the interaction as minor. Maprotiline and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative effects and may add to the drowsiness caused by maprotiline. The clinical effect is generally modest and is often used deliberately for sleep.
How serious is the interaction between Maprotiline and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about possible daytime drowsiness and reduce the melatonin dose or take it earlier in the evening if next-day sedation occurs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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