Drug interactions
Maprotiline + Methamphetamine
Severity: Major
Maprotiline and Methamphetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline blocks norepinephrine reuptake and methamphetamine releases catecholamines, so hypertension, tachycardia and arrhythmias may be intensified. Seizure risk is also increased and CYP2D6 inhibition may raise methamphetamine exposure.
What this interaction means in plain words
Maprotiline and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive noradrenergic stimulation and possible CYP2D6 inhibition by maprotiline.
What to do
Avoid the combination if possible. If it cannot be avoided, use low doses and monitor blood pressure, heart rate and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Maprotiline with Methamphetamine?
MediHelp rates the interaction as major. Maprotiline and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline blocks norepinephrine reuptake and methamphetamine releases catecholamines, so hypertension, tachycardia and arrhythmias may be intensified. Seizure risk is also increased and CYP2D6 inhibition may raise methamphetamine exposure.
How serious is the interaction between Maprotiline and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it cannot be avoided, use low doses and monitor blood pressure, heart rate and ECG.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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