Drug interactions
Maprotiline + Midodrine
Severity: Moderate
Maprotiline and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist and maprotiline increases noradrenergic tone, so the pressor response may be amplified, with a risk of marked hypertension and reflex bradycardia. The effect is less certain than with indirect sympathomimetics because midodrine acts directly.
What this interaction means in plain words
Maprotiline and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive alpha-adrenergic vasoconstriction and enhanced noradrenergic activity from reuptake blockade.
What to do
Monitor supine and seated blood pressure and heart rate, and reduce the midodrine dose if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Maprotiline with Midodrine?
MediHelp rates the interaction as moderate. Maprotiline and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist and maprotiline increases noradrenergic tone, so the pressor response may be amplified, with a risk of marked hypertension and reflex bradycardia. The effect is less certain than with indirect sympathomimetics because midodrine acts directly.
How serious is the interaction between Maprotiline and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and seated blood pressure and heart rate, and reduce the midodrine dose if hypertension occurs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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