Drug interactions
Maprotiline + Mirtazapine
Severity: Moderate
Maprotiline and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so together they may increase arrhythmia risk, especially with overdose or other risk factors. The combination also increases sedation and may add serotonergic effects.
What this interaction means in plain words
Maprotiline and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with additive sedative and serotonergic actions.
What to do
Obtain a baseline ECG and keep potassium and magnesium normal. Monitor for sedation and serotonin toxicity and avoid combining with further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Maprotiline with Mirtazapine?
MediHelp rates the interaction as moderate. Maprotiline and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so together they may increase arrhythmia risk, especially with overdose or other risk factors. The combination also increases sedation and may add serotonergic effects.
How serious is the interaction between Maprotiline and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and keep potassium and magnesium normal. Monitor for sedation and serotonin toxicity and avoid combining with further QT-prolonging drugs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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