Drug interactions
Maprotiline + Modafinil
Severity: Minor
Maprotiline and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant, whereas modafinil is a wake-promoting agent, so their effects on alertness may partly oppose each other. Modafinil may also modestly raise tricyclic-type antidepressant levels through CYP2C19 inhibition in some patients. The net effect is unpredictable.
What this interaction means in plain words
Maprotiline and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on alertness, with possible modafinil inhibition of CYP2C19 affecting antidepressant clearance.
What to do
Monitor for changes in sedation, anxiety and insomnia, and watch for maprotiline adverse effects such as anticholinergic effects or seizures. Adjust the maprotiline dose if tolerability changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maprotiline and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Maprotiline with Modafinil?
MediHelp rates the interaction as minor. Maprotiline and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline is a sedating tetracyclic antidepressant, whereas modafinil is a wake-promoting agent, so their effects on alertness may partly oppose each other. Modafinil may also modestly raise tricyclic-type antidepressant levels through CYP2C19 inhibition in some patients. The net effect is unpredictable.
How serious is the interaction between Maprotiline and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for changes in sedation, anxiety and insomnia, and watch for maprotiline adverse effects such as anticholinergic effects or seizures. Adjust the maprotiline dose if tolerability changes.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
