Drug interactions
Maprotiline + Propylhexedrine
Severity: Moderate
Maprotiline and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled indirect sympathomimetic decongestant. Maprotiline can alter its effects, and the combination may cause hypertension, tachycardia and arrhythmia, particularly with excessive use.
What this interaction means in plain words
Maprotiline and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Maprotiline blocks norepinephrine reuptake and the neuronal uptake of indirect sympathomimetics, altering the adrenergic response.
What to do
Prefer a non-sympathomimetic nasal option such as saline or an intranasal corticosteroid. If propylhexedrine is used, keep to labeled doses and monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Maprotiline with Propylhexedrine?
MediHelp rates the interaction as moderate. Maprotiline and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an inhaled indirect sympathomimetic decongestant. Maprotiline can alter its effects, and the combination may cause hypertension, tachycardia and arrhythmia, particularly with excessive use.
How serious is the interaction between Maprotiline and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sympathomimetic nasal option such as saline or an intranasal corticosteroid. If propylhexedrine is used, keep to labeled doses and monitor blood pressure and heart rate.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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