Drug interactions
Maprotiline + Risperidone
Severity: Major
Maprotiline and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, raising the risk of torsades de pointes, especially with other risk factors. Additive sedation and orthostatic hypotension may occur. Maprotiline may also increase risperidone exposure via CYP2D6 inhibition.
What this interaction means in plain words
Maprotiline and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression, with possible CYP2D6-mediated pharmacokinetic effects.
What to do
Perform a baseline ECG and monitor QTc and electrolytes during combined use. Watch for extrapyramidal symptoms and sedation and reduce the risperidone dose if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Maprotiline with Risperidone?
MediHelp rates the interaction as major. Maprotiline and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, raising the risk of torsades de pointes, especially with other risk factors. Additive sedation and orthostatic hypotension may occur. Maprotiline may also increase risperidone exposure via CYP2D6 inhibition.
How serious is the interaction between Maprotiline and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor QTc and electrolytes during combined use. Watch for extrapyramidal symptoms and sedation and reduce the risperidone dose if needed.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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