Drug interactions
Maprotiline + Rizatriptan
Severity: Moderate
Maprotiline and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with a serotonergic antidepressant has been reported to cause serotonin syndrome, though rarely. Maprotiline's weak serotonergic action suggests a low risk.
What this interaction means in plain words
Maprotiline and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from triptan receptor agonism and monoamine reuptake inhibition.
What to do
Counsel the patient on symptoms of serotonin syndrome and monitor after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Maprotiline with Rizatriptan?
MediHelp rates the interaction as moderate. Maprotiline and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with a serotonergic antidepressant has been reported to cause serotonin syndrome, though rarely. Maprotiline's weak serotonergic action suggests a low risk.
How serious is the interaction between Maprotiline and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome and monitor after dose changes.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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