Drug interactions
Maprotiline + Sevoflurane
Severity: Moderate
Maprotiline and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval, and maprotiline may do the same, so the risk of perioperative arrhythmia is increased. Tricyclic-type antidepressants can also increase sensitivity to arrhythmias and blood pressure swings under anesthesia.
What this interaction means in plain words
Maprotiline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization, with antidepressant-related adrenergic effects increasing arrhythmia susceptibility.
What to do
Inform the anesthesiologist and obtain a preoperative ECG. Maintain normal potassium and magnesium and monitor the ECG and hemodynamics during and after anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Maprotiline with Sevoflurane?
MediHelp rates the interaction as moderate. Maprotiline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval, and maprotiline may do the same, so the risk of perioperative arrhythmia is increased. Tricyclic-type antidepressants can also increase sensitivity to arrhythmias and blood pressure swings under anesthesia.
How serious is the interaction between Maprotiline and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesiologist and obtain a preoperative ECG. Maintain normal potassium and magnesium and monitor the ECG and hemodynamics during and after anesthesia.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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