Drug interactions
Maprotiline + Stiripentol
Severity: Moderate
Maprotiline and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and fatigue, which add to the sedation of maprotiline. Stiripentol also inhibits several CYP enzymes, which may increase maprotiline exposure. Maprotiline can lower seizure threshold in patients with epilepsy.
What this interaction means in plain words
Maprotiline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible CYP inhibition by stiripentol raising maprotiline concentrations.
What to do
Monitor sedation, seizure control and antidepressant adverse effects, and consider lowering maprotiline dose if toxicity occurs. Use an alternative antidepressant if seizures worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Maprotiline with Stiripentol?
MediHelp rates the interaction as moderate. Maprotiline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and fatigue, which add to the sedation of maprotiline. Stiripentol also inhibits several CYP enzymes, which may increase maprotiline exposure. Maprotiline can lower seizure threshold in patients with epilepsy.
How serious is the interaction between Maprotiline and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, seizure control and antidepressant adverse effects, and consider lowering maprotiline dose if toxicity occurs. Use an alternative antidepressant if seizures worsen.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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