Drug interactions
Maprotiline + Tiotropium-olodaterol
Severity: Moderate
Maprotiline and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline has anticholinergic properties that add to tiotropium, and it can prolong the QT interval and cause arrhythmias, which may be compounded by olodaterol. Tricyclic-type antidepressants can also potentiate the cardiovascular effects of beta2-agonists.
What this interaction means in plain words
Maprotiline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive cardiovascular and QT effects with the beta2-agonist.
What to do
Monitor heart rate, ECG in at-risk patients, and anticholinergic symptoms. Use the lowest effective doses and avoid in patients with significant arrhythmia history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Maprotiline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline has anticholinergic properties that add to tiotropium, and it can prolong the QT interval and cause arrhythmias, which may be compounded by olodaterol. Tricyclic-type antidepressants can also potentiate the cardiovascular effects of beta2-agonists.
How serious is the interaction between Maprotiline and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG in at-risk patients, and anticholinergic symptoms. Use the lowest effective doses and avoid in patients with significant arrhythmia history.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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