Drug interactions
Maprotiline + Valbenazine
Severity: Moderate
Maprotiline and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so combined use may raise the risk of ventricular arrhythmia including torsades de pointes. Risk rises with electrolyte disturbance, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Maprotiline and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization (QTc prolongation).
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Monitor the QTc and avoid combining further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Maprotiline with Valbenazine?
MediHelp rates the interaction as moderate. Maprotiline and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, so combined use may raise the risk of ventricular arrhythmia including torsades de pointes. Risk rises with electrolyte disturbance, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Maprotiline and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Monitor the QTc and avoid combining further QT-prolonging drugs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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