Drug interactions
Maraviroc + Nilotinib
Severity: Moderate
Maraviroc and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may increase maraviroc concentrations by inhibiting CYP3A4 and P-glycoprotein. Higher maraviroc exposure can increase adverse effects such as postural hypotension, hepatotoxicity and dizziness.
What this interaction means in plain words
Maraviroc and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of maraviroc by nilotinib.
What to do
Monitor for maraviroc adverse effects, including blood pressure and liver function. Consider maraviroc dose reduction if toxicity occurs, and monitor the nilotinib QT interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Nilotinib?
MediHelp rates the interaction as moderate. Maraviroc and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib may increase maraviroc concentrations by inhibiting CYP3A4 and P-glycoprotein. Higher maraviroc exposure can increase adverse effects such as postural hypotension, hepatotoxicity and dizziness.
How serious is the interaction between Maraviroc and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for maraviroc adverse effects, including blood pressure and liver function. Consider maraviroc dose reduction if toxicity occurs, and monitor the nilotinib QT interval.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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