Drug interactions
Maraviroc + Nortriptyline
Severity: Minor
Maraviroc and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is not a clinically meaningful CYP2D6 inhibitor at therapeutic doses, so a significant rise in nortriptyline exposure is not expected. Any interaction would be minor and unlikely to require action.
What this interaction means in plain words
Maraviroc and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Nortriptyline belongs to Central Nervous System.
Why it happens
Weak or negligible in vitro CYP2D6 inhibition by maraviroc; a clinically relevant effect has not been established.
What to do
No dose change is usually needed. Monitor for tricyclic adverse effects if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Nortriptyline?
MediHelp rates the interaction as minor. Maraviroc and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc is not a clinically meaningful CYP2D6 inhibitor at therapeutic doses, so a significant rise in nortriptyline exposure is not expected. Any interaction would be minor and unlikely to require action.
How serious is the interaction between Maraviroc and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for tricyclic adverse effects if symptoms appear.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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