Drug interactions
Maraviroc + Spironolactone
Severity: Minor
Maraviroc and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, particularly in patients with renal impairment or on other blood pressure lowering drugs. Spironolactone may add to this effect.
What this interaction means in plain words
Maraviroc and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Spironolactone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects; no pharmacokinetic interaction is established.
What to do
Counsel patients about dizziness on standing and monitor blood pressure after starting maraviroc. Adjust the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Spironolactone?
MediHelp rates the interaction as minor. Maraviroc and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc can cause postural hypotension, particularly in patients with renal impairment or on other blood pressure lowering drugs. Spironolactone may add to this effect.
How serious is the interaction between Maraviroc and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about dizziness on standing and monitor blood pressure after starting maraviroc. Adjust the antihypertensive dose if symptomatic.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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