Drug interactions
Maraviroc + Tocilizumab
Severity: Moderate
Maraviroc and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP3A4 and blocking IL-6 with tocilizumab can restore enzyme activity, potentially lowering levels of CYP3A4 substrates such as maraviroc. The effect would be most relevant at initiation or discontinuation of tocilizumab.
What this interaction means in plain words
Maraviroc and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Tocilizumab belongs to Musculoskeletal.
Why it happens
IL-6 blockade reverses cytokine-mediated downregulation of CYP3A4, increasing maraviroc metabolism.
What to do
Monitor HIV viral load and maraviroc response after starting tocilizumab. Adjust the maraviroc dose if needed based on the overall regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Tocilizumab?
MediHelp rates the interaction as moderate. Maraviroc and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chronic inflammation suppresses CYP3A4 and blocking IL-6 with tocilizumab can restore enzyme activity, potentially lowering levels of CYP3A4 substrates such as maraviroc. The effect would be most relevant at initiation or discontinuation of tocilizumab.
How serious is the interaction between Maraviroc and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and maraviroc response after starting tocilizumab. Adjust the maraviroc dose if needed based on the overall regimen.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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