Drug interactions
Maraviroc + Tolvaptan
Severity: Minor
Maraviroc and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein in vitro and could modestly raise exposure to maraviroc, a P-gp substrate. The clinical relevance is uncertain and is likely small.
What this interaction means in plain words
Maraviroc and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan may inhibit P-gp-mediated efflux of maraviroc, increasing its absorption and reducing its clearance.
What to do
No dose change is usually needed. Monitor for maraviroc adverse effects such as postural hypotension and hepatotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Tolvaptan?
MediHelp rates the interaction as minor. Maraviroc and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein in vitro and could modestly raise exposure to maraviroc, a P-gp substrate. The clinical relevance is uncertain and is likely small.
How serious is the interaction between Maraviroc and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for maraviroc adverse effects such as postural hypotension and hepatotoxicity.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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