Drug interactions
Maraviroc + Valsartan
Severity: Moderate
Maraviroc and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, and valsartan lowers blood pressure, so the combination may increase the risk of dizziness and orthostatic hypotension. This is more likely in patients with renal impairment or those taking other blood pressure lowering drugs.
What this interaction means in plain words
Maraviroc and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Valsartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects; maraviroc's postural hypotension is thought to relate to its pharmacology and is more frequent in renal impairment.
What to do
Monitor blood pressure including standing measurements, particularly in renal impairment. Advise patients to rise slowly and adjust valsartan if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Valsartan?
MediHelp rates the interaction as moderate. Maraviroc and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension, and valsartan lowers blood pressure, so the combination may increase the risk of dizziness and orthostatic hypotension. This is more likely in patients with renal impairment or those taking other blood pressure lowering drugs.
How serious is the interaction between Maraviroc and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing measurements, particularly in renal impairment. Advise patients to rise slowly and adjust valsartan if symptomatic hypotension occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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