Drug interactions
Marijuana + Silodosin
Severity: Moderate
Marijuana and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis may cause tachycardia and orthostatic hypotension and its cannabinoids weakly inhibit CYP3A4 in vitro. Combined with silodosin, dizziness or lowered blood pressure on standing may be more likely.
What this interaction means in plain words
Marijuana and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects, with possible weak CYP3A4 inhibition by cannabinoids.
What to do
Advise patients to rise slowly and monitor for orthostatic symptoms; reduce or stop cannabis use if dizziness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Marijuana and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Marijuana with Silodosin?
MediHelp rates the interaction as moderate. Marijuana and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis may cause tachycardia and orthostatic hypotension and its cannabinoids weakly inhibit CYP3A4 in vitro. Combined with silodosin, dizziness or lowered blood pressure on standing may be more likely.
How serious is the interaction between Marijuana and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to rise slowly and monitor for orthostatic symptoms; reduce or stop cannabis use if dizziness occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
