Drug interactions
Mechlorethamine + Secukinumab
Severity: Moderate
Mechlorethamine and Secukinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a cytotoxic alkylating agent that causes myelosuppression and immune suppression, and secukinumab raises the risk of infections. Combined use may increase the risk of serious infection. Mechlorethamine given systemically carries the greatest concern.
What this interaction means in plain words
Mechlorethamine and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Secukinumab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-17A blockade and cytotoxic bone marrow and lymphocyte suppression.
What to do
Monitor for signs of infection and blood counts during combined use. Screen for tuberculosis and consider holding secukinumab if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Secukinumab?
MediHelp rates the interaction as moderate. Mechlorethamine and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a cytotoxic alkylating agent that causes myelosuppression and immune suppression, and secukinumab raises the risk of infections. Combined use may increase the risk of serious infection. Mechlorethamine given systemically carries the greatest concern.
How serious is the interaction between Mechlorethamine and Secukinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and blood counts during combined use. Screen for tuberculosis and consider holding secukinumab if a serious infection develops.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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