Drug interactions
Medroxyprogesterone + Metformin-pioglitazone
Severity: Minor
Medroxyprogesterone and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Medroxyprogesterone, particularly the depot injection, may impair glucose tolerance and reduce the effect of antidiabetic therapy. The effect is generally modest.
What this interaction means in plain words
Medroxyprogesterone and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Progestogenic activity may increase insulin resistance and oppose antidiabetic effects.
What to do
Monitor blood glucose when starting or stopping medroxyprogesterone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Medroxyprogesterone and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Medroxyprogesterone, particularly the depot injection, may impair glucose tolerance and reduce the effect of antidiabetic therapy. The effect is generally modest.
How serious is the interaction between Medroxyprogesterone and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping medroxyprogesterone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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