Drug interactions
Medroxyprogesterone + Metformin-repaglinide
Severity: Minor
Medroxyprogesterone and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Medroxyprogesterone may impair glucose tolerance and reduce the effectiveness of antidiabetic drugs. The effect is usually modest but may be relevant with depot dosing.
What this interaction means in plain words
Medroxyprogesterone and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Progestin-related reduction in insulin sensitivity antagonizes antidiabetic effects.
What to do
Monitor blood glucose after starting or stopping medroxyprogesterone and adjust therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Metformin-repaglinide?
MediHelp rates the interaction as minor. Medroxyprogesterone and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Medroxyprogesterone may impair glucose tolerance and reduce the effectiveness of antidiabetic drugs. The effect is usually modest but may be relevant with depot dosing.
How serious is the interaction between Medroxyprogesterone and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping medroxyprogesterone and adjust therapy if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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