Drug interactions
Medroxyprogesterone + Nelfinavir
Severity: Moderate
Medroxyprogesterone and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may raise medroxyprogesterone concentrations. This could intensify progestin adverse effects, although clinical significance is usually limited.
What this interaction means in plain words
Medroxyprogesterone and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4, reducing medroxyprogesterone clearance.
What to do
Monitor for progestin adverse effects and adjust the dose if needed. Note nelfinavir can also lower ethinylestradiol levels, so review the contraceptive plan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Medroxyprogesterone with Nelfinavir?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may raise medroxyprogesterone concentrations. This could intensify progestin adverse effects, although clinical significance is usually limited.
How serious is the interaction between Medroxyprogesterone and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestin adverse effects and adjust the dose if needed. Note nelfinavir can also lower ethinylestradiol levels, so review the contraceptive plan.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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