Drug interactions
Medroxyprogesterone + Oxcarbazepine
Severity: Major
Medroxyprogesterone and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower medroxyprogesterone concentrations and reduce contraceptive or therapeutic effect. Contraceptive failure is the main concern.
What this interaction means in plain words
Medroxyprogesterone and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Medroxyprogesterone belongs to Endocrine; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, accelerating medroxyprogesterone metabolism.
What to do
Use a non-enzyme-dependent contraceptive such as an IUD, or add a barrier method. Monitor for breakthrough bleeding and therapeutic response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Oxcarbazepine?
MediHelp rates the interaction as major. Medroxyprogesterone and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may lower medroxyprogesterone concentrations and reduce contraceptive or therapeutic effect. Contraceptive failure is the main concern.
How serious is the interaction between Medroxyprogesterone and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-enzyme-dependent contraceptive such as an IUD, or add a barrier method. Monitor for breakthrough bleeding and therapeutic response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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