Drug interactions
Medroxyprogesterone + Rifabutin
Severity: Moderate
Medroxyprogesterone and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can reduce progestin concentrations, potentially compromising contraceptive efficacy. The induction effect is weaker than with rifampicin but still clinically relevant.
What this interaction means in plain words
Medroxyprogesterone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4, accelerating the metabolism of medroxyprogesterone.
What to do
Advise an additional or alternative non-hormonal contraceptive method during rifabutin therapy and for a few weeks after stopping. Injectable depot medroxyprogesterone is less affected, but counsel the patient about the risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Medroxyprogesterone with Rifabutin?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and can reduce progestin concentrations, potentially compromising contraceptive efficacy. The induction effect is weaker than with rifampicin but still clinically relevant.
How serious is the interaction between Medroxyprogesterone and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during rifabutin therapy and for a few weeks after stopping. Injectable depot medroxyprogesterone is less affected, but counsel the patient about the risk.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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