Drug interactions
Mefenamic acid + Moxifloxacin
Severity: Moderate
Mefenamic acid and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAID use may increase fluoroquinolone-related CNS stimulation and seizure risk. Mefenamic acid itself has convulsant potential in overdose. Patients with epilepsy or CNS disease are most vulnerable.
What this interaction means in plain words
Mefenamic acid and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold, with fluoroquinolone GABA-A antagonism possibly enhanced by NSAIDs.
What to do
Avoid in patients with seizure disorders or CNS risk factors. Otherwise watch for tremor, agitation or seizures and consider a different analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Mefenamic acid with Moxifloxacin?
MediHelp rates the interaction as moderate. Mefenamic acid and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAID use may increase fluoroquinolone-related CNS stimulation and seizure risk. Mefenamic acid itself has convulsant potential in overdose. Patients with epilepsy or CNS disease are most vulnerable.
How serious is the interaction between Mefenamic acid and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders or CNS risk factors. Otherwise watch for tremor, agitation or seizures and consider a different analgesic.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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