Drug interactions
Mefenamic acid + Ospemifene
Severity: Moderate
Mefenamic acid and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid is a CYP2C9 substrate and may compete with or modestly inhibit metabolism of ospemifene, and both are highly protein bound. Increased exposure to either drug is possible but clinical significance is unclear.
What this interaction means in plain words
Mefenamic acid and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Ospemifene belongs to Endocrine.
Why it happens
Competition for CYP2C9 metabolism and plasma protein binding sites.
What to do
Monitor for ospemifene adverse effects such as hot flushes and thromboembolic events, and for NSAID adverse effects; use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Mefenamic acid with Ospemifene?
MediHelp rates the interaction as moderate. Mefenamic acid and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid is a CYP2C9 substrate and may compete with or modestly inhibit metabolism of ospemifene, and both are highly protein bound. Increased exposure to either drug is possible but clinical significance is unclear.
How serious is the interaction between Mefenamic acid and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects such as hot flushes and thromboembolic events, and for NSAID adverse effects; use the lowest effective doses.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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