Drug interactions
Mefenamic acid + Torsemide
Severity: Moderate
Mefenamic acid and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effects of loop diuretics and increase the risk of kidney injury, especially in volume-depleted patients. Reduced natriuresis may worsen heart failure or edema.
What this interaction means in plain words
Mefenamic acid and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, counteracting loop diuretic action.
What to do
Monitor weight, blood pressure, edema and serum creatinine, and adjust the diuretic dose if response drops. Limit NSAID duration and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Torsemide
Frequently asked questions
Can I take Mefenamic acid with Torsemide?
MediHelp rates the interaction as moderate. Mefenamic acid and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effects of loop diuretics and increase the risk of kidney injury, especially in volume-depleted patients. Reduced natriuresis may worsen heart failure or edema.
How serious is the interaction between Mefenamic acid and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, blood pressure, edema and serum creatinine, and adjust the diuretic dose if response drops. Limit NSAID duration and maintain hydration.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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