Drug interactions
Mefloquine + Nisoldipine
Severity: Moderate
Mefloquine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may increase nisoldipine exposure through CYP3A4 inhibition, causing hypotension, edema or reflex tachycardia. Mefloquine can also affect cardiac conduction.
What this interaction means in plain words
Mefloquine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Nisoldipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition reduces nisoldipine first-pass metabolism, with possible additive cardiac effects.
What to do
Monitor blood pressure and heart rate and titrate nisoldipine to effect. Reduce the dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Mefloquine with Nisoldipine?
MediHelp rates the interaction as moderate. Mefloquine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine may increase nisoldipine exposure through CYP3A4 inhibition, causing hypotension, edema or reflex tachycardia. Mefloquine can also affect cardiac conduction.
How serious is the interaction between Mefloquine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate nisoldipine to effect. Reduce the dose if hypotension or edema develops.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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