Drug interactions
Mefloquine + Osilodrostat
Severity: Moderate
Mefloquine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mefloquine and osilodrostat are associated with QT interval prolongation. Using them together may increase the risk of torsades de pointes, especially with electrolyte abnormalities or underlying cardiac disease.
What this interaction means in plain words
Mefloquine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Osilodrostat belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic effects.
What to do
Check ECG and serum potassium and magnesium before starting and periodically during co-therapy. Correct electrolyte deficits and consider an alternative antimalarial if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Mefloquine with Osilodrostat?
MediHelp rates the interaction as moderate. Mefloquine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mefloquine and osilodrostat are associated with QT interval prolongation. Using them together may increase the risk of torsades de pointes, especially with electrolyte abnormalities or underlying cardiac disease.
How serious is the interaction between Mefloquine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and serum potassium and magnesium before starting and periodically during co-therapy. Correct electrolyte deficits and consider an alternative antimalarial if the QTc becomes markedly prolonged.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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