Drug interactions
Mefloquine + Osimertinib
Severity: Moderate
Mefloquine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib and mefloquine can each lengthen the QT interval. Co-administration may increase the likelihood of serious ventricular arrhythmia, particularly in patients with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Mefloquine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of the QTc interval through pharmacodynamic effects.
What to do
Perform periodic ECG monitoring and keep potassium and magnesium within normal range. Withhold or change therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Mefloquine with Osimertinib?
MediHelp rates the interaction as moderate. Mefloquine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib and mefloquine can each lengthen the QT interval. Co-administration may increase the likelihood of serious ventricular arrhythmia, particularly in patients with electrolyte disturbances or cardiac disease.
How serious is the interaction between Mefloquine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and keep potassium and magnesium within normal range. Withhold or change therapy if QTc becomes markedly prolonged.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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