Drug interactions
Mefloquine + Pomalidomide
Severity: Minor
Mefloquine and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine inhibits P-glycoprotein and could raise pomalidomide exposure. Pomalidomide is mainly cleared by CYP1A2 and CYP3A4, and P-gp is a minor pathway, so the clinical effect is likely small and not well documented.
What this interaction means in plain words
Mefloquine and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefloquine belongs to Anti Parasitic; Pomalidomide belongs to Miscellaneous.
Why it happens
Mefloquine may inhibit P-glycoprotein-mediated efflux of pomalidomide, which is a P-gp substrate.
What to do
No dose change is usually required. Monitor for pomalidomide adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Mefloquine with Pomalidomide?
MediHelp rates the interaction as minor. Mefloquine and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine inhibits P-glycoprotein and could raise pomalidomide exposure. Pomalidomide is mainly cleared by CYP1A2 and CYP3A4, and P-gp is a minor pathway, so the clinical effect is likely small and not well documented.
How serious is the interaction between Mefloquine and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for pomalidomide adverse effects such as neutropenia.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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