Drug interactions
Mefloquine + Solifenacin
Severity: Moderate
Mefloquine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can prolong the QT interval and cause bradycardia, and solifenacin has a minor additive QT effect. The combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Mefloquine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and electrolytes before co-administration in patients with cardiac risk factors. Consider an alternative antimalarial or hold solifenacin during the course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Solifenacin?
MediHelp rates the interaction as moderate. Mefloquine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can prolong the QT interval and cause bradycardia, and solifenacin has a minor additive QT effect. The combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Mefloquine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before co-administration in patients with cardiac risk factors. Consider an alternative antimalarial or hold solifenacin during the course.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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