Drug interactions
Mefloquine + Tazemetostat
Severity: Moderate
Mefloquine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine has been described as a CYP3A4 inhibitor, and tazemetostat is metabolized by CYP3A4, so tazemetostat levels may rise. This could increase tazemetostat adverse effects.
What this interaction means in plain words
Mefloquine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Tazemetostat belongs to Miscellaneous.
Why it happens
Possible CYP3A4 inhibition by mefloquine reduces tazemetostat metabolism.
What to do
Monitor for tazemetostat adverse effects such as cytopenias and fatigue. Consider an alternative antimalarial if the combination is poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mefloquine and Tazemetostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Mefloquine with Tazemetostat?
MediHelp rates the interaction as moderate. Mefloquine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine has been described as a CYP3A4 inhibitor, and tazemetostat is metabolized by CYP3A4, so tazemetostat levels may rise. This could increase tazemetostat adverse effects.
How serious is the interaction between Mefloquine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat adverse effects such as cytopenias and fatigue. Consider an alternative antimalarial if the combination is poorly tolerated.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
