Drug interactions
Mefloquine + Tizanidine
Severity: Moderate
Mefloquine and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tizanidine and mefloquine have been associated with QT interval prolongation, so combining them may add to arrhythmia risk. Tizanidine's QT effect is modest, and the clinical significance is greatest with other risk factors such as electrolyte disturbances or heart disease.
What this interaction means in plain words
Mefloquine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities in at-risk patients. Avoid the combination in patients with known long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Tizanidine?
MediHelp rates the interaction as moderate. Mefloquine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both tizanidine and mefloquine have been associated with QT interval prolongation, so combining them may add to arrhythmia risk. Tizanidine's QT effect is modest, and the clinical significance is greatest with other risk factors such as electrolyte disturbances or heart disease.
How serious is the interaction between Mefloquine and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities in at-risk patients. Avoid the combination in patients with known long QT or other QT-prolonging drugs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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