Drug interactions
Mefloquine + Vemurafenib
Severity: Major
Mefloquine and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and vemurafenib labeling advises against combining it with other QT-prolonging drugs. The combination may increase the risk of serious arrhythmia.
What this interaction means in plain words
Mefloquine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mefloquine belongs to Anti Parasitic; Vemurafenib belongs to Oncology.
Why it happens
Additive QTc prolongation through pharmacodynamic effects.
What to do
Avoid the combination if possible. If it cannot be avoided, monitor ECG and electrolytes and correct abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Mefloquine with Vemurafenib?
MediHelp rates the interaction as major. Mefloquine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and vemurafenib labeling advises against combining it with other QT-prolonging drugs. The combination may increase the risk of serious arrhythmia.
How serious is the interaction between Mefloquine and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it cannot be avoided, monitor ECG and electrolytes and correct abnormalities.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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