Drug interactions
Mefloquine + Vorinostat
Severity: Moderate
Mefloquine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and mefloquine may add to this effect. The combination may modestly increase arrhythmia risk, particularly with electrolyte disturbances.
What this interaction means in plain words
Mefloquine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Vorinostat belongs to Oncology.
Why it happens
Additive QTc prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and keep potassium and magnesium within normal range. Monitor the QTc during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Mefloquine with Vorinostat?
MediHelp rates the interaction as moderate. Mefloquine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and mefloquine may add to this effect. The combination may modestly increase arrhythmia risk, particularly with electrolyte disturbances.
How serious is the interaction between Mefloquine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and keep potassium and magnesium within normal range. Monitor the QTc during combined use.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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