Drug interactions
Melatonin + Metaxalone
Severity: Minor
Melatonin and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative properties and may modestly add to metaxalone-related drowsiness. The effect is usually small and short-lived.
What this interaction means in plain words
Melatonin and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Metaxalone belongs to Musculoskeletal.
Why it happens
Mild additive central nervous system depressant effect.
What to do
Advise the patient to take melatonin at bedtime and avoid driving if drowsy. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Metaxalone?
MediHelp rates the interaction as minor. Melatonin and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative properties and may modestly add to metaxalone-related drowsiness. The effect is usually small and short-lived.
How serious is the interaction between Melatonin and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to take melatonin at bedtime and avoid driving if drowsy. No dose change is usually needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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