Drug interactions
Melatonin + Methoxsalen
Severity: Moderate
Melatonin and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen is a potent CYP1A2 inhibitor and can markedly raise melatonin concentrations. This may cause prolonged daytime drowsiness and sedation.
What this interaction means in plain words
Melatonin and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Melatonin belongs to Gastrointestinal Tract; Methoxsalen belongs to Anti Fungals.
Why it happens
Methoxsalen inhibits CYP1A2, the main enzyme metabolizing melatonin, reducing its clearance.
What to do
Use the lowest melatonin dose and monitor for excessive sedation, or avoid melatonin during methoxsalen therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Melatonin and Methoxsalen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Melatonin with Methoxsalen?
MediHelp rates the interaction as moderate. Melatonin and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen is a potent CYP1A2 inhibitor and can markedly raise melatonin concentrations. This may cause prolonged daytime drowsiness and sedation.
How serious is the interaction between Melatonin and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest melatonin dose and monitor for excessive sedation, or avoid melatonin during methoxsalen therapy.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
