Drug interactions
Melatonin + Orphenadrin
Severity: Minor
Melatonin and Orphenadrin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative properties, and orphenadrine can cause drowsiness and dizziness. Together there may be a small increase in daytime sleepiness and impaired alertness.
What this interaction means in plain words
Melatonin and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive mild CNS depressant effects.
What to do
Usually no change is needed; advise taking melatonin at bedtime and being cautious with driving if drowsy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orphenadrin
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Orphenadrin?
MediHelp rates the interaction as minor. Melatonin and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative properties, and orphenadrine can cause drowsiness and dizziness. Together there may be a small increase in daytime sleepiness and impaired alertness.
How serious is the interaction between Melatonin and Orphenadrin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; advise taking melatonin at bedtime and being cautious with driving if drowsy.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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