Drug interactions
Melatonin + Quetiapine
Severity: Minor
Melatonin and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative effects that may add to the sedation caused by quetiapine. Increased daytime drowsiness is possible, but serious harm is unlikely.
What this interaction means in plain words
Melatonin and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Additive sedative effects; no significant pharmacokinetic interaction is established.
What to do
Counsel the patient about additive drowsiness and take both at bedtime. Reduce the melatonin dose if daytime sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Quetiapine?
MediHelp rates the interaction as minor. Melatonin and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative effects that may add to the sedation caused by quetiapine. Increased daytime drowsiness is possible, but serious harm is unlikely.
How serious is the interaction between Melatonin and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and take both at bedtime. Reduce the melatonin dose if daytime sedation occurs.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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