Drug interactions
Melatonin + Secobarbital
Severity: Minor
Melatonin and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative properties that may add to the hypnotic effect of secobarbital. This can cause greater next-day drowsiness and impaired alertness.
What this interaction means in plain words
Melatonin and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Secobarbital belongs to Central Nervous System.
Why it happens
Additive sedative effects; no pharmacokinetic mechanism established.
What to do
Monitor for excessive daytime drowsiness and avoid driving if impaired. Reduce one agent if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Secobarbital?
MediHelp rates the interaction as minor. Melatonin and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative properties that may add to the hypnotic effect of secobarbital. This can cause greater next-day drowsiness and impaired alertness.
How serious is the interaction between Melatonin and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive daytime drowsiness and avoid driving if impaired. Reduce one agent if sedation is troublesome.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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