Drug interactions
Meloxicam + Ticlopidine
Severity: Moderate
Meloxicam and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C9 and may raise meloxicam exposure, increasing the risk of NSAID adverse effects. In addition, both drugs impair hemostasis, so bleeding risk is increased.
What this interaction means in plain words
Meloxicam and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2C9-mediated meloxicam metabolism, and both drugs have additive antiplatelet or GI-bleeding effects.
What to do
Monitor for GI bleeding and other NSAID adverse effects, and use the lowest effective meloxicam dose. Consider an alternative analgesic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Meloxicam with Ticlopidine?
MediHelp rates the interaction as moderate. Meloxicam and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C9 and may raise meloxicam exposure, increasing the risk of NSAID adverse effects. In addition, both drugs impair hemostasis, so bleeding risk is increased.
How serious is the interaction between Meloxicam and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and other NSAID adverse effects, and use the lowest effective meloxicam dose. Consider an alternative analgesic if possible.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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